Portable Plasma? Enter Entegrion’s Resusix

On the front lines(click to view full) Your friend is on the ground, bleeding out. If you can’t replace the lost circulation volume, he’ll die quickly from shock. If the replacement you use hinders clotting, his odds to make it through the Golden Hour aren’t good. The bad news? Because of your location, frozen blood plasma isn’t available. Entegrion, Inc. in Durham, NC thinks they have an answer, and the US Army is funding it with up to $43.8 million, to advance Resusix through phase II and phase III trials. What is Resusix? (click to view full) It’s a temporary blood substitute. The Pentagon describes it as “Spray Dried Pooled Plasma.” Entegrion describes it as a “dehydrated, pathogen inactivated human plasma-based therapeutic for use in resuscitation… shelf-stable… that can be used to replace volume lost in bleeding, while maintaining functional blood clotting factors.” The dry plasma powder and the reconstitution fluid are currently stored in 2 separate bags, connected by tubing. To use Resusix, break the seal, and the fluid and powder are mixed and delivered. Resusix will be Entegrion’s first Investigational New Drug (IND) filing, and the firm expects 10-15 clinical investigation sites to participate in each phase of […]